Novel Roles of Placental Allopregnanolone in Brain Development and Injury
This grant supports the use of new molecular and mouse models to test the role of key placental hormones in normal brain development and how their loss may contribute to injury.

Sponsor:       NIH/NICHD

Grant Type: R01

PI: Anna A. Penn, MD/PhD

District of Columbia Intellectual and Developmental Disabilities Research Center
The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDD), develop innovative therapies, and prevent or attenuate these disorders. Collaborating DC academic medical centers (Children’s National Health System (lead), George Washington University, Howard University, and Georgetown University) work together to promote translational research and training opportunities, supported by the Clinical Translational Core (CTC) which provides assistance at each stage of the clinical and translational research spectrum and optimizes efficient, high quality implementation of fundamental research.

Sponsor: NIH/NICHD

Grant Type: U54

PI: Vittorio Gallo, PhD

Protection and Repair of Preterm Cerebellum by Allopregnanolone

This grant supports cord blood hormone measurements across gestational ages, longitudinal assessment of neonatal hormone levels in extremely preterm infants and preclinical hormone treatment assessment

Sponsor: Research Foundation of Cerebal Palsy Alliance

Grant Type: Foundation

PI: Anna A. Penn, MD, PhD

Board of Visitors Perinatal Neuroprotection Program

This grant supports development of multi-disciplinary team focused on improving outcomes in extremely preterm infants, including support for preterm neurological monitoring, preclinical investigation of neuroprotective hormones and specialized fellow training at Children’s National Medical Center.

Sponsor:   Board of Visitors

Grant Type: Foundation

PI: Anna A. Penn, MD, PhD

Linking Preterm Birth and ASD risk with cerebellar white matter

This grant focuses on how placental ALLO insufficiency impairs cerebellar myelination and to compare Akr1c14plKO cerebellar network alterations to established ASD models.

Sponsor: SFARI (Simons Foundation)

Grant Type: Foundation

PI: Anna A. Penn, MD, PhD